Publications and Presentations

  1. Rophael J, Shaw C, Yii M. Hypoglycaemia Associated with a Massive Thoracic Cavity Tumour
    Cardiothoracic Care Centre, St.Vincent’s Hospital, Melbourne
    Moderated Poster Presentation at Annual Scientific Congress
    3-5-2004, RACS
  2. Rophael J, Wright G. A Novel Approach to the Management of Tracheopathia Osteochondroplastica
    Cardiothoracic Care Centre, St.Vincent’s Hospital, Melbourne
    Moderated Poster Presentation at Annual Scientific Congress
    3-5-2004, RACS
  3. Rophael J, Mitchell G, Penington A, Morrison W.
    Angiogenesis and Adipogenesis in a Murine Model under the influence of VEGF A, FGF 2 and PDGF B. Bernard O’Brien Institute of Microsurgery.
    Presentation at Annual Scientific Congress
    3-5-2004, RACS.
  4. Chan P, Murphy M, McKelvie P, Rophael J, Trost N.
    An Unusual Case of Skull Metastasis of Hepatocellular Carcinoma- Case Report and Literature Review, Department of Neurosurgery, Neuropathology and Neuroradiology, St.Vincent’s Hospital, Melbourne. ANZ J Surg.
    2004 Aug;74(8):710-713.
  5. Mitchell G, Lokmic Z, Penington A, Rophael J, Stillaert F, Morrison W. Bernard O’Brien Institute of Microsurgery.
    The role of vascularisation in three dimensional tissue engineering.
    Presentation by G Mitchell at 7th World Biomaterials Congress 21-5-04, Sydney
  6. Kenneth R Knight, Yoshiaki Uda, Michael W Findlay, David L Brown  Kevin J Cronin, Emma Jamieson, Effie Keramidaris, Anthony J Penington, John Rophael, Leonard C Harrison, Wayne A Morrison.
    Vascularized tissue-engineered chambers promote survival and function of transplanted islets and improve glycemic control. FASEB J. 2006 Mar; 20(3): 565-7
  7. Findlay, Michael W.; Uda, Yoshiaki; Rophael, John; Jamieson, Emma; Keramidaris, Effie; Penington, Anthony J.; Knight, Kenneth R.; Morrison, Wayne A.
    Renewing a Role for Microsurgery in Transplantation Medicine? Site-Directed Tissue Engineering of Pancreas and Liver. World Society of Reconstructive Microsurgery (WSRM) III Congress, Buenos Aires, Argentina, 23-26/10/2005; J Reconstr Microsurgery 2006:22
  8. Hemmrich K, Thomas GPL, Abberton KM, Thompson EW, Rophael JA, Penington AJ, Morrison WA.
    Monocyte chemoattractant protein-1 and nitric oxide promote adipogenesis in a model that mimics obesity.
    Obesity 2007 Dec: 15(12): 2951-7
  9. Rophael JA, Craft RO, Palmer JA, Hussey AJ, Thomas GPL, Penington A, Morrison WA, Mitchell GM.
    Growth Factor Synergism in a Murine Tissue-Engineering Model of Angiogenesis and Adipogenesis. Am J Pathol 2007 Dec, 171(6):2048-2057
  10. Craft RO, Rophael JA, Thompson E, Morrison WA, Vashi AV, Mitchell GM, Penington AJ.
    Effect of Local, Long-Term Delivery of Platelet Derived Growth Factor (PDGF) on Injected  Fat-Graft Survival in SCID Mice. J Plast Reconstr Aesthet Surg. 2008 Jan 4: [Epub ahead of print]
  11. Clopidogrel cessation in non cardiac surgery and the role of tirofiban.
    Presentation to the NSW Society of Vascular Surgery April 2008
  12. Seach N, Mattesich M,  Abberton K,  Matsuda K, Rophael JA, Boyd RL,  Morrison WA.
    Vascularized Tissue Engineering Mouse Chamber Model Supports Thymopoiesis of Ectopic Thymic Tissue Grafts. Tissue Engineering: Part C 2009 Oct,  15(00):1-9
  13. Hsu CCT, Kwan GNC,van Driel ML, Rophael JA.
    Venous cutdown versus the Seldinger technique for placement of totally implantable venous access ports (Protocol). Cochrane Database of Systematic Reviews, Issue 1. Art No: CD008942
  14. Hsu CCT, Rophael JA, Kwan GNC, van Driel ML.
    Percutaneous transluminal arterial angioplasty versus stenting for infrapopliteal lesions in critical limb ischaemia (Review 1533). Cochrane Database of Systematic Reviews 2010.
  15. Hsu CCT, Kwan GNC, van Driel ML, Rophael JA.
    Distal aortic perfusion during thoracoabdominal aneurysm repair for prevention of paraplegia (Review 1531).
    Cochrane Database of Systematic Reviews 2010, Issue 1. Art No: CD008197
  16. Hsu CCT, Kwan GNC, Rophael JA, van Driel ML.
    Vascular closure devices versus manual compression for arterial puncture sites (Review 1534).
    Cochrane Database of Systematic Reviews 2010
  17. Chin LC, Kumar P, Palmer JA, Rophael JA, Dolderer JH, Thomas GP, Morrison WA, Penington AJ, Stewart AG, Mitchell GM.  The influence of nitric oxide synthase 2 on cutaneous wound angiogenesis  Br J Dermatol.
    2011 Dec;165(6):1223-35. doi: 10.1111/j.1365-2133.2011.10599.x.
  18. Chin L, Kumar P, Palmer J, Rophael J, Dolderer J, Penington A, Stewart A, Mitchell G. The role of Nitric Oxide Synthase 2 (NOS 2) on angiogenesis and wound healing.
    36th Annual Scientific Meeting of the Australian and New Zealand Burn Association
    9 – 12 October 2012 Hobart.

Pub. No.: WO/2008/019434
International Application No.: PCT/AU2007/001149
Publication Date: 21.02.2008
International Filing Date: 14.08.2007

The present invention relates generally to the use of agents to enhance adipogenesis and to promote fat graft survival in mammalian subjects. More particularly, the present invention contemplates the use of growth factors delivered by local or sustained administration alone or in combination with a range of growth factors to enhance angiogenesis in association with adipogenesis and to promote fat graft survival to thereby improve weight maintenance and to preserve normal cellular architecture of tissue including free fat grafts in mammalian subjects. Compositions comprising the instant agents also form part of the present invention.

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